Aluminium phosphide (ALP) and aluminium zinc phosphide (ZnP), the two main ingredients of fumigation drugs, are commonly used to kill insects or rodents in grain. When exposed to water, highly toxic phosphine gas is released and absorbed through the respiratory or digestive tract. Phosphine gas could non-selectively block cytochrome oxidase, inhibit electron transfer and suppress oxidative phosphorylation, leading to cellular hypoxia and organ dysfunction. The characteristic clinical manifestations are refractory shock and metabolic acidosis with high mortality. However, patients with ALP poisoning have a chance to be cured. Here, we report a case of oral ALP poisoning that was successfully treated by extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy (CRRT) during frequent ventricular fibrillation and cardiac dysfunction.

磷化铝（ALP）和磷化铝锌（ZnP）是熏蒸药物的两种主要成分，常用于杀灭粮食中的昆虫或鼠类。当接触水时，会释放出剧毒的磷化氢气体，并通过呼吸道或消化道吸收。磷化氢气体可以非选择性地阻断细胞色素氧化酶，抑制电子传递，抑制氧化磷酸化，导致细胞缺氧和器官功能障碍。其特征性临床表现为难治性休克和代谢性酸中毒，死亡率高。但是，碱性磷酸酶中毒的患者有治愈的机会。这里，