Penta-substituted cyclohexanes were synthesized from α,β-unsaturated aldehydes and α-acetyl-β-aryl-α,β-unsaturated esters in excellent diastereo- and enantioselectivity. Three continuous stereocenters were controlled by diphenylprolinol silyl ether-mediated domino Michael/Michael reaction, followed by epimerization to thermodynamically favored compound.

中文翻译：

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通过二苯基脯氨醇甲硅烷基醚介导的多米诺迈克尔/迈克尔反应不对称合成五取代环己烷

由α,β-不饱和醛和α-乙酰基-β-芳基-α,β-不饱和酯以优异的非对映选择性和对映选择性合成五取代环己烷。三个连续立体中心由二苯基脯氨醇甲硅烷基醚介导的多米诺迈克尔/迈克尔反应控制，然后差向异构化为热力学有利的化合物。