Novel functionalized indolines were synthesized from 2-(((N-aryl)amino)methyl)acrylates and formamides under ultrasonic irradiation for the first time. Aiming to develop a straightforward and easy-to-implement methodology for the synthesis of indolines, an instrumentation setup was designed, including ultrasound (US) equipment (Ultrasonic Horn; tip diameter of 12.7 mm, 20 kHz, maximum power of 400 W), an open reaction flask, and an inexpensive and green catalyst (1 mol%; FeSO₄·7H₂O; CAS: 7782–63–0) without the need for anhydrous conditions. The use of the sono-Fenton process in the presence of formamides and 2-(((N-aryl)amino)methyl)acrylates afforded a broad range of functionalized indolines within 60 s in high yields. Several experimental parameters of the ultrasound-assisted reaction were evaluated, such as amplitude (40–80%), sonication time (15–60 s), and pulsed ultrasonic irradiation. A 60 s silent reaction did not produce the desired indoline. The optimized conditions for US-mediated reactions allowed the production of functionalized indolines in high isolated yields (up to 99%, 60 s reaction, pulse ration 1 s:1 s, US amplitude 60 %).

首次在超声辐照下由 2-((( N-芳基)氨基)甲基)丙烯酸酯和甲酰胺合成了新型功能化二氢吲哚。为了开发一种简单且易于实施的二氢吲哚合成方法，设计了一种仪器设置，包括超声（美国）设备（超声波喇叭；尖端直径为 12.7 毫米，20 kHz，最大功率为 400 W），一个开放式反应烧瓶，以及一种廉价且绿色的催化剂（1 mol%；FeSO ₄ ·7H ₂ O；CAS：7782-63-0），无需无水条件。在甲酰胺和 2-((( N-芳基）氨基）甲基）丙烯酸酯在 60 秒内以高产率提供了广泛的官能化二氢吲哚。评估了超声辅助反应的几个实验参数，例如振幅（40-80%）、超声处理时间（15-60 秒）和脉冲超声辐照。60 秒的静默反应没有产生所需的二氢吲哚。US 介导反应的优化条件允许以高分离产率生产官能化二氢吲哚（高达 99%，60 秒反应，脉冲比 1 秒：1 秒，US 振幅 60%）。