Devising synthetic strategies to construct a covalent bond is a common research topic among synthetic chemists. A key driver of success is the high tunability of the conditions, including catalysts, reagents, solvents, and reaction temperature. Such flexibility of synthetic operations has allowed for the rapid exploration of a myriad of artificial synthetic transformations in recent decades. However, if we turn our attention to chemical reactions controlled in living cells, the situation is quite different; the number of hit substrates for the reaction-type is relatively small, while the crowded environment is chemically complex and inflexible to control.

中文翻译：

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Propargylic Se-adenosyl-l-selenomethionine：甲基化分析的化学工具

设计合成策略以构建共价键是合成化学家的共同研究课题。成功的关键驱动因素是条件的高度可调性，包括催化剂、试剂、溶剂和反应温度。近几十年来，合成操作的这种灵活性使人们能够快速探索无数的人工合成转化。然而，如果我们将注意力转向活细胞中控制的化学反应，情况就大不相同了。反应型的hit底物数量相对较少，而拥挤的环境化学复杂且难以控制。