Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.

死于 COVID-19 的人中有多达 50% 患有代谢和血管疾病。值得注意的是，COVID-19 与代谢和内分泌系统之间存在许多直接联系。因此，不仅患有代谢功能障碍（例如肥胖、高血压、非酒精性脂肪肝和糖尿病）的患者患重症 COVID-19 的风险增加，而且感染 SARS-CoV-2 可能导致新的-糖尿病发作或原有代谢紊乱的加重。在这篇综述中，我们更新了代谢和内分泌失调如何使患者易患重症 COVID-19 的机制。此外，我们更新了针对 COVID-19 和大流行后患者的实用建议和管理。此外，我们总结了针对 COVID-19 和糖尿病患者的新治疗方案，