Cytomegalovirus (CMV) retinitis in patients with Non-Hodgkin’s Lymphoma (NHL) can occur even in the presence of high CD 4 counts and can behave differently when compared to CMV retinitis in human immunodeficiency (HIV) patients. It, therefore, becomes important to understand its varied presentations and the challenges in management of these cases. The aim of this study was to analyse the various patterns of presentations and outcomes of CMV Retinitis in patients with NHL. A retrospective chart review of seven eyes of four patients of NHL presenting with CMV retinitis between June 2017 and May 2020 was done. Clinical patterns of CMV Retinitis, CD4 counts at the time of presentation and the duration of treatment along with recurrences and time for recurrence of retinitis were assessed. Granular or indolent retinitis (6 out of 7 eyes) was the commonest form of CMV retinitis in patients of NHL. Three patients had a presenting CD4 count above 150 cells/mm3 and none of them were below 50 cells/mm3. Floaters were the commonest presenting complaint. All patients had vitritis and majority of the patients (3 out of 4) had anterior chamber (AC) inflammation. Two out of the 4 patients had a recurrence (mean time 33.8 days) after stopping the maintenance phase of ganciclovir and one patient had significant myelosuppression related to oral valganciclovir which required discontinuation of the drug. CMV retinitis in NHL patients is usually of an indolent or granular type and can occur even in the presence of high CD4 counts as compared to patients with HIV. These patients may require a long term maintenance in view of frequent recurrences after discontinuation of treatment.

中文翻译：

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非霍奇金淋巴瘤患者的巨细胞病毒视网膜炎：临床表现和结果

即使存在高 CD 4 计数，非霍奇金淋巴瘤 (NHL) 患者的巨细胞病毒 (CMV) 视网膜炎也可能发生，并且与人类免疫缺陷 (HIV) 患者的 CMV 视网膜炎相比，其表现可能有所不同。因此，了解其不同的表现形式和管理这些案例的挑战变得很重要。本研究的目的是分析 NHL 患者 CMV 视网膜炎的各种表现模式和结果。对 2017 年 6 月至 2020 年 5 月期间出现 CMV 视网膜炎的四名 NHL 患者的七只眼睛进行了回顾性图表审查。评估了 CMV 视网膜炎的临床模式、出现时的 CD4 计数和治疗持续时间以及复发和视网膜炎复发的时间。颗粒状或惰性视网膜炎（7 只眼中有 6 只眼）是 NHL 患者中最常见的 CMV 视网膜炎形式。三名患者的 CD4 计数高于 150 个细胞/mm3，没有一个低于 50 个细胞/mm3。飞蚊症是最常见的投诉。所有患者都患有玻璃体炎，大多数患者（4 名中的 3 名）患有前房 (AC) 炎症。4 名患者中有 2 名在停止更昔洛韦维持期后复发（平均时间为 33.8 天），1 名患者出现与口服缬更昔洛韦相关的显着骨髓抑制，需要停药。NHL 患者的 CMV 视网膜炎通常为惰性或颗粒型，与 HIV 患者相比，即使存在高 CD4 计数也可能发生。