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Gender Matching Did Not Affect 2-year Rejection or Failure Rates Following DSAEK for Fuchs Endothelial Corneal Dystrophy
American Journal of Ophthalmology ( IF 4.2 ) Pub Date : 2021-10-06 , DOI: 10.1016/j.ajo.2021.09.029
Vito Romano 1 , Mohit Parekh 2 , Gianni Virgili 3 , Giulia Coco 4 , Pia Leon 5 , Katja Islein 6 , Diego Ponzin 7 , Stefano Ferrari 7 , Adriano Fasolo 8 , Angeli Christy Yu 9 , Ersilia Lucenteforte 10 , Massimo Busin 9 , Stephen B Kaye 1
Affiliation  

Purpose

To investigate whether donor to recipient gender or H-Y mismatching was associated with graft rejection or failure following Descemet stripping automated endothelial keratoplasty (DSAEK) in patients with Fuchs endothelial corneal dystrophy (FECD).

Design

Clinical cohort study.

Methods

This study used a multi-center registry including patients aged >18 years who had undergone their first DSAEK for FECD between January 2008 and March 2018. The impact of donor and recipient gender incompatibility (including H-Y mismatches) on corneal graft rejection and failure was evaluated using Kaplan-Meier curves and univariable and multivariable Cox models.

Results

Outcome data from 4341 eyes (3915 from the UK and 426 from Italy) were analyzed. Graft failure at 2-year follow-up occurred in 477 (11.0%) cases. Graft rejection at 2-year follow-up occurred in 175 cases (4.0%), 58 (1.3%) of whom developed graft failure. There was no significant effect of gender or H-Y mismatching on either rejection (P = .12, P = .06) or failure (P = .28, P = .14), respectively.

Conclusions

In patients with FECD undergoing DSAEK, no significant influence of gender and or H-Y mismatch on graft rejection or failure was found.



中文翻译:

性别匹配不影响 Fuchs 角膜内皮营养不良 DSAEK 后 2 年的拒绝或失败率

目的

研究 Fuchs 角膜内皮营养不良 (FECD) 患者的后弹力剥离自动内皮角膜移植术 (DSAEK) 后,供体与受体性别或 HY 不匹配是否与移植物排斥或失败有关。

设计

临床队列研究。

方法

本研究使用多中心登记,包括 2008 年 1 月至 2018 年 3 月期间为 FECD 接受首次 DSAEK 的 18 岁以上患者。评估了供体和受体性别不相容(包括 HY 不匹配)对角膜移植排斥和失败的影响使用 Kaplan-Meier 曲线和单变量和多变量 Cox 模型。

结果

分析了 4341 只眼睛(3915 只来自英国,426 只来自意大利)的结果数据。477 例 (11.0%) 病例在 2 年随访中出现移植失败。175 例(4.0%)在 2 年的随访中出现移植排斥,其中 58 例(1.3%)出现移植失败。性别或 HY 不匹配分别对拒绝 ( P  = .12, P  = .06) 或失败 ( P  = .28, P  = .14)没有显着影响。

结论

在接受 DSAEK 的 FECD 患者中,未发现性别和/或 HY 不匹配对移植排斥或失败的显着影响。

更新日期:2021-12-11
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