A Common Variant at 11q23.3 Is Associated with Susceptibility to Atopic Dermatitis in the Han Chinese Population,Genetic Testing and Molecular Biomarkers

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A Common Variant at 11q23.3 Is Associated with Susceptibility to Atopic Dermatitis in the Han Chinese Population
Genetic Testing and Molecular Biomarkers ( IF 1.4 ) Pub Date : 2021-10-18 , DOI: 10.1089/gtmb.2020.0335
Yang Li _{1,

2} , Feng-Li Xiao _{1,

2} , Hui Cheng _{1,

2} , Bo Liang _{1,

2} , Fu-Sheng Zhou _{1,

2} , Pan Li _{1,

2} , Xiao-Dong Zheng _{1,

2} , Liang-Dan Sun _{1,

2} , Sen Yang _{1,

2} , Xue-Jun Zhang _{1,

2}

Affiliation

Background: Genome-wide association studies (GWASs) have identified many genetic variants that are risk factors for numerous immune-mediated diseases. In particular, different immune-mediated diseases have been found to share the same susceptibility loci. Therefore, exploring the genetic overlap between atopic dermatitis (AD) and other immune-mediated diseases in more detail may help identify additional shared susceptibility loci among common immune-mediated diseases. Recent evidence suggests that the 11q23.3 locus is a susceptibility locus shared among multiple immune-mediated diseases.

中文翻译：

11q23.3 的一个常见变异与汉族人群对特应性皮炎的易感性有关

背景：全基因组关联研究 (GWAS) 已经确定了许多遗传变异，这些变异是许多免疫介导疾病的危险因素。特别是，已发现不同的免疫介导疾病具有相同的易感基因座。因此，更详细地探索特应性皮炎 (AD) 和其他免疫介导疾病之间的遗传重叠可能有助于确定常见免疫介导疾病之间的其他共享易感位点。最近的证据表明，11q23.3 基因座是多种免疫介导疾病共有的易感基因座。

更新日期：2021-10-22

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