Objective

To evaluate long-term reproductive outcomes in couples who were enrolled in a large randomized controlled trial that studied optimal treatment for unexplained infertility.

Design

Telephone survey, administered between March 2019 and February 2020.

Setting

Large urban university-affiliated fertility center.

Patient(s)

Couples who enrolled in the Fast Track and Standard Treatment Trial (FASTT).

Intervention(s)

None.

Main Outcomes Measure(s)

Number of live births, methods of conception, adoption, and satisfaction regarding family size.

Result(s)

Of the 503 couples enrolled in FASTT, 311 (61.8%) were contacted and 286 (56.9%) consented to participate. The mean age and follicle-stimulating hormone level at the time of enrollment in FASTT were 33.1 ± 3.2 years and 6.8 ± 2.2 mIU/mL, respectively, for those who participated in this study. The mean age at follow-up was 49.5 ± 3.4 years. Of the 286 women, 194 (67.8%) had a live birth during the trial and 225 (78.7%) continued to try to conceive after FASTT. Of those who tried to conceive without treatment, 101 of 157 (64.3%) had a successful live birth, whereas 12 (5.3%) women had a live birth via intrauterine insemination and 82 (36.4%) via autologous oocyte in vitro fertilization. Overall, 182 (80.9%) women achieved a live birth after FASTT.

Conclusion(s)

The majority of couples were able to achieve a live birth after FASTT. Only 19 (6.6%) never achieved a live birth during their reproductive years. Moving to treatment sooner allows the opportunity to achieve >1 live birth, which is associated with increased satisfaction regarding family size. This further supports access to care and insurance coverage for infertility treatment.

中文翻译：

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不明原因不孕症患者的长期生殖结局：快速通道和标准治疗试验参与者的随访

客观的

评估参加一项大型随机对照试验的夫妇的长期生殖结果，该试验研究了不明原因不孕症的最佳治疗方法。

设计

电话调查，于 2019 年 3 月至 2020 年 2 月期间进行。

环境

大型城市大学附属生育中心。

耐心）

参加快速通道和标准治疗试验 (FASTT) 的夫妇。

干预措施

没有。

主要成果衡量标准

活产数量、受孕方法、收养和对家庭规模的满意度。

结果）

在参加 FASTT 的 503 对夫妇中，联系了 311 对（61.8%），286 对（56.9%）同意参加。参加本研究的人在 FASTT 登记时的平均年龄和促卵泡激素水平分别为 33.1 ± 3.2 岁和 6.8 ± 2.2 mIU/mL。随访的平均年龄为 49.5 ± 3.4 岁。在 286 名女性中，194 名（67.8%）在试验期间活产，225 名（78.7%）在 FASTT 后继续尝试怀孕。在未经治疗尝试受孕的人中，157 名妇女中有 101 名（64.3%）成功活产，而 12 名（5.3%）妇女通过宫内授精活产，82 名（36.4%）妇女通过自体卵母细胞体外受精活产。总体而言，182 名 (80.9%) 女性在 FASTT 后实现了活产。

结论

大多数夫妇在 FASTT 后能够实现活产。只有 19 人（6.6%）在生育期间从未实现过活产。越早接受治疗，就有机会实现 >1 次活产，这与增加对家庭规模的满意度有关。这进一步支持获得不孕症治疗的护理和保险。