Minimal data exist about the incidence and risk factors for arch intervention after comprehensive stage II (CSII). Goal of this study was to document incidence of arch interventions after CSII and determine if any differences existed between those who underwent an arch intervention (aiCSII) versus those did not have an intervention. Single-center retrospective chart review of all hypoplastic left heart syndrome patients who underwent a CSII between 6/1/2005 and 2/1/2020 was performed. Univariate analysis was conducted in addition to principal components analysis (PCA). One hundred patients were evaluated. Sixteen patients underwent 24 arch interventions. Age at initial arch reintervention was 1.3 ± 1.2 years (median 1.0 years, range 0.5–2.2 years). Univariate analysis showed that the aiCSII group were more likely to be female, to have had a retrograde arch intervention post-hybrid procedure, and to be younger at time of CSII. On echocardiograms, aiCSII group had significantly higher pre-CSII patent ductus arteriosus velocities, arch velocities on their 1st post-operative and discharge study post-CSII, and arch velocities pre-Fontan. Gradients were higher in the aiCSII via pre-Fontan catheterization. With PCA, echocardiographic and catheterization data remained significantly associated with aiCSII versus those who did not undergo an arch intervention (OR = 4.5 (1.9, 19.8), p = 0.008). Incidence of arch intervention post-CSII was 16%. Echocardiographic arch velocities during the CSII hospitalization were the strongest predictors for subsequent aortic arch interventions. Further studies are needed to determine any modifiable variables that may reduce the incidence of arch interventions.

关于综合 II 期 (CSII) 后牙弓介入治疗的发生率和危险因素的数据很少。本研究的目标是记录 CSII 后足弓干预的发生率，并确定接受足弓干预 (aiCSII) 与未接受足弓干预的患者之间是否存在差异。对所有在 2005 年 6 月 1 日至 2020 年 2 月 1 日之间接受 CSII 的左心发育不全综合征患者进行了单中心回顾性图表审查。除了主成分分析（PCA）外，还进行了单变量分析。一百名患者进行了评估。16 名患者接受了 24 次足弓干预。初始足弓再介入的年龄为 1.3 ± 1.2 岁（中位数 1.0 岁，范围 0.5-2.2 岁）。单变量分析显示，aiCSII 组更可能是女性，在混合手术后进行了逆行弓干预，并且在CSII时更年轻。在超声心动图上，aiCSII 组在CSII 前的动脉导管未闭速度、第一次术后和出院研究中的弓速度和Fontan 前的弓速度显着提高。通过 pre-Fontan 导管插入 aiCSII 的梯度更高。对于 PCA，超声心动图和导管插入术数据与 aiCSII 与未接受弓形干预的患者相比仍然显着相关（OR = 4.5 (1.9, 19.8)，通过 pre-Fontan 导管插入 aiCSII 的梯度更高。对于 PCA，超声心动图和导管插入术数据与 aiCSII 与未接受弓形干预的患者相比仍然显着相关（OR = 4.5 (1.9, 19.8)，通过 pre-Fontan 导管插入 aiCSII 的梯度更高。对于 PCA，超声心动图和导管插入术数据与 aiCSII 与未接受弓形干预的患者相比仍然显着相关（OR = 4.5 (1.9, 19.8)，p  = 0.008）。CSII 后足弓干预的发生率为 16%。CSII 住院期间的超声心动图弓速度是后续主动脉弓干预的最强预测因素。需要进一步的研究来确定可能降低足弓干预发生率的任何可修改变量。