Nitric oxide (NO) is a short-lived, bioactive gas that has been found to have affinitive effects on cardiovascular diseases as well as cancer biology, while NO deficiency may cause serious pathological responses. The existing chemically-synthesized NO donors have inevitable systemic toxicity and cannot be released adaptively. Hence, L-arginine, an endogenous NO precursor, merits investigation as a natural efficient NO donor. Herein, we designed amino acid-doped L-arginine CDs-based bioenzyme-responsive NO donors, which could adaptively replenish NO/ONOO⁻ in response to different microenvironments. Our results indicated the mechanism of the NO/ONOO⁻ supplementation of L-arginine-based CDs and their potential for nonpharmaceutical gas-involving theranostics for the first time.

中文翻译：

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生物酶反应性 L-精氨酸基碳点：补充一氧化氮用于非药物治疗

一氧化氮 (NO) 是一种短寿命的生物活性气体，已被发现对心血管疾病和癌症生物学具有亲和作用，而 NO 缺乏可能会导致严重的病理反应。现有的化学合成的 NO 供体具有不可避免的全身毒性，不能适应性释放。因此，L-精氨酸是一种内源性 NO 前体，作为天然有效的 NO 供体值得研究。在此，我们设计了基于氨基酸掺杂的L-精氨酸 CDs 的生物酶响应性 NO 供体，它可以响应不同的微环境自适应地补充 NO/ONOO ^-。我们的结果表明 NO/ONOO 的机制^-补充L-基于精氨酸的 CD 及其首次用于非药物气体治疗诊断学的潜力。