We report the rational design of a tunable Cu(II) chelating scaffold, 2-(((2-((pyridin-2-ylmethyl)amino)ethyl)amino)methyl)phenol, Salpyran (HL). This tetradentate ligand is predicated to have suitable permeation, has an extremely high affinity for Cu compared to clioquinol (pCu_7.4 = 10.65 vs 5.91), and exhibits excellent selectivity for Cu(II) over Zn(II) in aqueous media. Solid and solution studies corroborate the formation of a stable [Cu(II)L]⁺ monocationic species at physiological pH values (7.4). Its action as an antioxidant was tested in ascorbate, tau, and human prion protein assays, which reveal that Salpyran prevents the formation of reactive oxygen species from the binary Cu(II)/H₂O₂ system, demonstrating its potential use as a therapeutic small molecule metal chelator.

中文翻译：

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Salpyran：具有治疗潜力的 Cu(II) 选择性螯合剂

我们报告了可调 Cu(II) 螯合支架、2-(((2-((pyridin-2-ylmethyl)amino)ethyl)amino)methyl)phenol、Salpyran (HL) 的合理设计。据推测，这种四齿配体具有合适的渗透性，与氯碘羟喹相比对 Cu 具有极高的亲和力（pCu _7.4 = 10.65 vs 5.91），并且在水性介质中对 Cu(II) 的选择性优于对 Zn(II) 的选择性。固体和溶液研究证实了在生理 pH 值 (7.4)下形成了稳定的 [Cu(II)L] ^{+单阳离子物质。}其作为抗氧化剂的作用在抗坏血酸盐、tau 和人类朊病毒蛋白测定中进行了测试，结果表明Salpyran可防止二元 Cu(II)/H ₂ O _{2形成活性氧。} 系统，展示了其作为治疗性小分子金属螯合剂的潜在用途。