Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication,Antimicrobial Agents and Chemotherapy

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Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-10-04 , DOI: 10.1128/aac.01398-21
Sari Mattila ₁ , Pirjo Merilahti ₁ , Sarah Wazir ₂ , Tania Quirin ₁ , Mirko M Maksimainen _{2,

3} , Yuezhou Zhang ₄ , Henri Xhaard ₄ , Lari Lehtiö _{2,

3} , Tero Ahola ₁

Affiliation

Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses. In this study, compound MRS ...

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