Identification of a proteasome-targeting arylsulfonamide with potential for the treatment of Chagas’ disease,Antimicrobial Agents and Chemotherapy

当前位置： X-MOL 学术 › Antimicrob. Agents Chemother. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Identification of a proteasome-targeting arylsulfonamide with potential for the treatment of Chagas’ disease
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-10-04 , DOI: 10.1128/aac.01535-21
Marta L Lima ₁ , Lindsay B Tulloch ₁ , Victoriano Corpas-Lopez ₁ , Sandra Carvalho ₁ , Richard J Wall ₁ , Rachel Milne ₁ , Eva Rico ₁ , Stephen Patterson ₁ , Ian H Gilbert , Sonia Moniz ₁ , Lorna MacLean ₂ , Leah S Torrie ₂ , Carmine Morgillo ₂ , David Horn ₁ , Fabio Zuccotto ₂ , Susan Wyllie ₁

Affiliation

Phenotypic screening identified an arylsulfonamide compound with activity against Trypanosoma cruzi, the causative agent of Chagas’ disease. Comprehensive mode of action studies revealed that this compound primarily targets the T. cruzi proteasome, ...

中文翻译：