Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan,Antimicrobial Agents and Chemotherapy

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Isolation of Group A Streptococci with Reduced In Vitro β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-10-04 , DOI: 10.1128/aac.01482-21
Tsubasa Ikeda ₁ , Rihito Suzuki ₁ , Wanchun Jin ₁ , Jun-Ichi Wachino ₁ , Yoshichika Arakawa ₁ , Kouji Kimura ₁

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Streptococcus pyogenes (group A Streptococcus, GAS) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein (PBP)2X conferring reduced in vitro β-lactam susceptibility have been indicated ...

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