The Oklahoma Shock Nathan Shock Center is designed to deliver unique, innovative services that are not currently available at most institutions. The focus of the Center is on geroscience and the development of careers of young investigators. Pilot grants are provided through the Research Development Core to junior investigators studying aging/geroscience throughout the USA. However, the services of our Center are available to the entire research community studying aging and geroscience. The Oklahoma Nathan Shock Center provides researchers with unique services through four research cores. The Multiplexing Protein Analysis Core uses the latest mass spectrometry technology to simultaneously measure the levels, synthesis, and turnover of hundreds of proteins associated with pathways of importance to aging, e.g., metabolism, antioxidant defense system, proteostasis, and mitochondria function. The Genomic Sciences Core uses novel next-generation sequencing that allows investigators to study the effect of age, or anti-aging manipulations, on DNA methylation, mitochondrial genome heteroplasmy, and the transcriptome of single cells. The Geroscience Redox Biology Core provides investigators with a comprehensive state-of-the-art assessment of the oxidative stress status of a cell, e.g., measures of oxidative damage and redox couples, which are important in aging as well as many major age-related diseases as well as assays of mitochondrial function. The GeroInformatics Core provides investigators assistance with data analysis, which includes both statistical support as well as analysis of large datasets. The Core also has developed number of unique software packages to help with interpretation of results and discovery of new leads relevant to aging. In addition, the Geropathology Research Resource in the Program Enhancement Core provides investigators with pathological assessments of mice using the recently developed Geropathology Grading Platform.

Oklahoma Shock Nathan Shock Center 旨在提供目前大多数机构无法提供的独特创新服务。该中心的重点是老年科学和年轻研究人员的职业发展。试点拨款通过研究发展核心提供给全美研究衰老/老年科学的初级研究人员。但是，我们中心的服务可供研究衰老和老年科学的整个研究团体使用。俄克拉荷马州内森休克中心通过四个研究核心为研究人员提供独特的服务。多重蛋白质分析核心使用最新的质谱技术同时测量与衰老重要途径相关的数百种蛋白质的水平、合成和周转，例如新陈代谢、抗氧化防御系统、蛋白质稳态和线粒体功能。Genomic Sc​​iences Core 使用新颖的下一代测序，使研究人员能够研究年龄或抗衰老操作对 DNA 甲基化、线粒体基因组异质性和单细胞转录组的影响。Geroscience Redox Biology Core 为研究人员提供了对细胞氧化应激状态的综合最新评估，例如，氧化损伤和氧化还原对的测量，这在衰老以及许多与年龄相关的主要方面都很重要疾病以及线粒体功能的测定。GeroInformatics Core 为调查人员提供数据分析方面的帮助，包括统计支持和大型数据集分析。Core 还开发了许多独特的软件包，以帮助解释结果和发现与衰老相关的新线索。此外，程序增强核心中的老年病理学研究资源为研究人员提供了使用最近开发的老年病理学分级平台对小鼠进行的病理学评估。