Prior investigation has suggested a positive association between increased colonic propionate production and circulating odd-chain fatty acids (OCFAs; pentadecanoic acid [C15:0], heptadecanoic acid [C17:0]). As the major source of propionate in humans is the microbial fermentation of dietary fiber, OCFAs have been proposed as candidate biomarkers of dietary fiber. The objective of this study is to critically assess the plausibility, robustness, reliability, dose-response, time-response aspects of OCFAs as potential biomarkers of fermentable fibers in two independent studies using a validated analytical method.

中文翻译：

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奇数链脂肪酸不是膳食纤维摄入的可靠生物标志物

先前的研究表明结肠丙酸产量增加与循环奇数链脂肪酸（OCFA；十五烷酸 [C15:0]、十七烷酸 [C17:0]）之间存在正相关关系。由于人类丙酸盐的主要来源是膳食纤维的微生物发酵，因此已提出 OCFA 作为膳食纤维的候选生物标志物。本研究的目的是在两项使用经过验证的分析方法的独立研究中，批判性地评估 OCFA 作为可发酵纤维的潜在生物标志物的合理性、稳健性、可靠性、剂量反应、时间反应方面。