American Journal of Transplantation ( IF 8.8 ) Pub Date : 2021-10-03 , DOI: 10.1111/ajt.16863 Mesut Tez 1
I have read the manuscript entitled “Pure laparoscopic living donor liver transplantation: Dreams come true”,1 and I congratulate the authors. However, I think that some points must be clarified.
The Oxford dictionary defines “dream”, as “… a wish to have or be something, especially one that seems difficult to achieve.” Is “Pure laparoscopic living donor liver transplantation” a dream? In my opinion, no. The authors stated that “total operative time was 960 min—3/4 day—and this procedure must be performed by a highly experienced surgeon and transplantation team—new learning curve—."1
I believe the dream of a transplant surgeon or patient would be the following: liver transplantation without rejection, liver transplantation without graft failure, and liver transplantation without immunosuppressants (may be artificial or bioartificial liver).
- Normal Science: Scientific research is not hindered by the model's limits.
- Model Drift: At this stage, problems and anomalies start to accumulate (eg, graft rejection); they arise, and the paradigm finds it difficult to address them.
- Model Crisis: The paradigm reaches a critical moment and becomes unable to address the new challenges at all. Since the main problem cannot be answered, secondary topics such as the technical details of surgical procedures begin to be discussed more (eg, laparoscopic living donor liver transplantation).
- Model Revolution: At this moment, some experts start to promote the idea of the need for a new paradigm to replace the broken one.
- Paradigm Shift: These serious attempts will be crowned with a successful paradigm shift, the old is abandoned, and the new one replaces it.2
In conclusion, although I congratulate the researchers for this complex surgery, laparoscopic liver transplantation could not be described as “a dream” nor “a paradigm shift.”
中文翻译:
点评“纯腹腔镜活体肝移植:梦想成真”
我已阅读题为“纯腹腔镜活体肝移植:梦想成真”的手稿,1我向作者表示祝贺。但是,我认为有几点必须澄清。
牛津词典将“梦想”定义为“……拥有或成为某物的愿望,尤其是那些似乎难以实现的愿望。” “纯腹腔镜活体肝移植”是梦吗?在我看来,没有。作者指出,“总手术时间为 960 分钟——3/4 天——并且该手术必须由经验丰富的外科医生和移植团队执行——新的学习曲线——” 1
我相信移植外科医生或患者的梦想应该是:无排斥反应的肝移植、无移植失败的肝移植、无免疫抑制剂(可能是人工肝或生物人工肝)的肝移植。
- 常态科学:科学研究不受模型限制的阻碍。
- 模型漂移:在此阶段,问题和异常开始累积(例如,移植物排斥);它们出现了,范式发现很难解决它们。
- 模型危机:范式到了关键时刻,变得根本无法应对新的挑战。由于无法回答主要问题,因此开始更多地讨论外科手术的技术细节等次要主题(例如,腹腔镜活体肝移植)。
- 模型革命:此时,一些专家开始提倡需要一种新的范式来取代坏掉的范式。
- 范式转变:这些认真的尝试将以成功的范式转变为加冕,旧的被抛弃,新的取而代之。2个
总之,虽然我祝贺研究人员完成了这项复杂的手术,但腹腔镜肝移植不能被描述为“梦想”或“范式转变”。