Ascending aortic aneurysms (AsAA) often include the dilatation of sinotubular junction (STJ) which usually leads to aortic insufficiency. The novel surgery of the V-shape resection of the noncoronary sinus, for treatment of AsAA with root ectasia, has been shown to be a simpler procedure compared to traditional surgeries. Our previous study showed that the repaired aortic root aneurysms grew after the surgery. In this study, we developed a novel computational growth framework to model the growth of the aortic root repaired by the V-shape surgery. Specifically, the unified-fiber-distribution (UFD) model was applied to describe the hyperelastic deformation of the aortic tissue. A novel kinematic growth evolution law was proposed based on existing observations that the growth rate is linearly dependent on the wall stress. Moreover, we also obtained patient-specific geometries of the repaired aortic root post-surgery at two follow-up time points (Post1 and Post2) for 5 patients, based on clinical CT images. The novel computational growth framework was implemented into the Abaqus UMAT user subroutine and applied to model the growth of the aortic root from Post1 to Post2. Patient-specific growth parameters were obtained by an optimization procedure. The predicted geometry and stress of the aortic root at Post2 agree well with the in vivo results. The novel computational growth framework and the optimized growth parameters could be applied to predict the growth of repaired aortic root aneurysms for new patients and to optimize repair strategies for AsAA.

中文翻译：

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生物组织的计算生长框架：在 V 形手术修复的主动脉根部动脉瘤生长中的应用

升主动脉瘤 (AsAA) 通常包括窦管交界处 (STJ) 的扩张，这通常会导致主动脉瓣关闭不全。与传统手术相比，新的非冠状窦 V 形切除术用于治疗伴有牙根扩张的 AsAA，已被证明是一种更简单的手术。我们之前的研究表明，修复后的主动脉根部动脉瘤在手术后生长。在这项研究中，我们开发了一种新的计算生长框架来模拟 V 形手术修复的主动脉根部的生长。具体而言，统一纤维分布 (UFD) 模型被应用于描述主动脉组织的超弹性变形。基于现有观察结果，生长速率与壁应力呈线性关系，提出了一种新的运动学生长演化规律。而且，我们还根据临床 CT 图像，在 5 名患者的两个随访时间点（Post1 和 Post2）获得了手术后修复的主动脉根部的患者特定几何形状。新的计算增长框架被实施到 Abaqus UMAT 用户子程序中，并应用于模拟主动脉根从 Post1 到 Post2 的增长。通过优化程序获得患者特定的生长参数。Post2 处主动脉根部的预测几何形状和应力与 通过优化程序获得患者特定的生长参数。Post2 处主动脉根部的预测几何形状和应力与 通过优化程序获得患者特定的生长参数。Post2 处主动脉根部的预测几何形状和应力与体内结果。新的计算生长框架和优化的生长参数可用于预测新患者修复的主动脉根部动脉瘤的生长，并优化 AsAA 的修复策略。