The enzyme-based cellulose nanofibers from lemongrass waste were used as a potential carrier for the sustained release of curcumin, a natural anticancer polyphenol against different cancers. However, its low bioavailability, solubility and suboptimal pharmacokinetic issues limit its use in cancer therapeutics. The curcumin was encapsulated into the cellulose nanofibers with the highest encapsulation efficiency of ∼ 99% through homogeneous monolayer adsorption. Further, the binding of curcumin onto the cellulose nanofibers and its morphology were confirmed by FT-IR, molecular interaction study and SEM analysis. The controlled release profile of the encapsulated curcumin was determined at different simulated pH conditions, i.e., 1.2, 5.3, 6.8 and 7.4. At all pH conditions, the highest correlation was observed in Korsmeyer-peppas equation, indicating release occurred through diffusion. Moreover, the nanocomposite conserves the efficacy of curcumin in PC3 cell lines. Hence, the results suggest that the enzyme-based cellulose nanofibers are a good candidate for controlled release for curcumin without hindering its efficacy, which may be applied for pharmaceutical applications.

来自柠檬草废料的酶基纤维素纳米纤维被用作持续释放姜黄素的潜在载体，姜黄素是一种针对不同癌症的天然抗癌多酚。然而，其低生物利用度、溶解度和次优的药代动力学问题限制了其在癌症治疗中的应用。姜黄素通过均匀的单层吸附被包封到纤维素纳米纤维中，包封率最高，可达 99%。此外，通过 FT-IR、分子相互作用研究和 SEM 分析证实了姜黄素与纤维素纳米纤维的结合及其形态。在不同的模拟 pH 条件下确定包封姜黄素的控释曲线，即，1.2、5.3、6.8 和 7.4。在所有 pH 条件下，在 Korsmeyer-peppas 方程中观察到最高的相关性，表明通过扩散发生释放。此外，纳米复合材料保留了姜黄素在 PC3 细胞系中的功效。因此，结果表明基于酶的纤维素纳米纤维是姜黄素控释的良好候选者，不会影响其功效，可用于药物应用。