The administration of L-glutamine (Gln) suppresses allergic airway inflammation via the rapid upregulation of MAPK phosphatase (MKP)-1, which functions as a negative regulator of inflammation by deactivating p38 and JNK mitogen-activated protein kinases (MAPKs). However, the role of endogenous Gln remains to be elucidated. Therefore, we investigated the mechanism by which endogenous Gln regulates MKP-1 induction and allergic airway inflammation in an ovalbumin-based murine asthma model.

中文翻译：

---

谷氨酰胺缺乏将哮喘状态转变为中性粒细胞气道炎症

L-谷氨酰胺 (Gln) 的给药通过快速上调 MAPK 磷酸酶 (MKP)-1 来抑制过敏性气道炎症，MKP-1 通过失活 p38 和 JNK 丝裂原活化蛋白激酶 (MAPKs) 作为炎症的负调节剂。然而，内源性 Gln 的作用仍有待阐明。因此，我们在基于卵白蛋白的小鼠哮喘模型中研究了内源性 Gln 调节 MKP-1 诱导和过敏性气道炎症的机制。