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Chemical probe of AHL modulators on quorum sensing in Gram-Negative Bacteria and as antiproliferative agents: A review
European Journal of Medicinal Chemistry ( IF 6.7 ) Pub Date : 2021-10-02 , DOI: 10.1016/j.ejmech.2021.113864
Maxwell Ampomah-Wireko 1 , Chunying Luo 1 , Yaquan Cao 1 , Huanhuan Wang 1 , Lauraine Nininahazwe 1 , Chunli Wu 1
Affiliation  

Pathogenic bacteria use an intercellular chemical communication system called quorum sensing (QS) to control the expression of cellular functions such as virulence factors, biofilm formation, toxin production, and antibiotic resistance in a manner that is highly dependent on population density. Hence, since the emergence of QS, there has been a great interest in exploiting the QS mechanism as a new drug target. Therefore, blocking the QS mechanism can be an effective strategy to control infection and solve the problem of drug resistance. So far, there is no clinically approved anti-QS drug that can disable the circuits of QS systems. This review discusses the quorum-sensing network systems and novel anti-QS inhibitors in some Gram-negative bacteria.



中文翻译:

AHL 调节剂对革兰氏阴性菌群体感应和作为抗增殖剂的化学探针:综述

病原菌使用称为群体感应 (QS) 的细胞间化学通讯系统以高度依赖于种群密度的方式控制细胞功能的表达,例如毒力因子、生物膜形成、毒素产生和抗生素耐药性。因此,自从 QS 出现以来,人们对利用 QS 机制作为新的药物靶点产生了极大的兴趣。因此,阻断QS机制可以成为控制感染、解决耐药问题的有效策略。到目前为止,还没有临床批准的可以禁用 QS 系统电路的抗 QS 药物。这篇综述讨论了一些革兰氏阴性菌中的群体感应网络系统和新型抗 QS 抑制剂。

更新日期:2021-10-07
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