Steam-distilled oregano (Lippia origanoides) distillation process was analyzed and described as a model binary mixture. The most abundant identified and selected compounds were pinocembrin, a high-value flavonoid, as representative of the minor fraction, and octacosane, a cuticular wax, of the major fraction. Thermodynamic solubility of the solid multicomponent mixture in supercritical CO₂ was measured at 313 K and 323 K, and pressures from 8.6 to 32.1 MPa, using a dynamic-analytical method with on-line HPLC analysis. The molar fraction of pinocembrin in CO₂-rich phase was assessed from 4.8·10⁻⁶ to 33·10⁻⁶ mol/mol. The solid + fluid equilibrium for the ternary model system was modeled with the Peng-Robinson equation of state and the classical van der Waals mixing rules. Extraction experiments of the solid multicomponent mixture with supercritical CO₂ modified with 2–9% w/w ethanol, were carried out in a one-pass pilot scale apparatus at 308 K, 323 K and 338 K, and pressures of 18 MPa, 26 MPa, and 34 MPa. For each sample, the pinocembrin content was assessed. The extraction curves for oleoresin and pinocembrin were represented with empirical models from which the oleoresin partition constants were estimated, that were in range from 0.03 to 0.13 kg/kg substrate/CO₂ depending on extraction conditions. However, the partition constant remained virtually invariant, independently of changes in the extraction temperature and pressure conditions, and the ethanol content in CO₂, with an average value of 0.08 kg/kg substrate/CO₂. These results will facilitate using a simplified mass transfer model to describe oleoresin extraction from steam-distilled L. origanoides.

对蒸汽蒸馏牛至 ( Lippia origanoides ) 蒸馏过程进行了分析并将其描述为模型二元混合物。鉴定和选择的最丰富的化合物是松香素（一种高价值的黄酮类化合物），作为次要部分的代表，以及二十八烷（一种角质蜡），是主要部分的代表。固体多组分混合物在超临界 CO _{2 中的}热力学溶解度在 313 K 和 323 K 以及 8.6 至 32.1 MPa 的压力下使用具有在线 HPLC 分析的动态分析方法测量。富CO ₂相中松柏素的摩尔分数评估为4.8·10 ^-6至33·10 ^-6摩尔/摩尔。三元模型系统的固体 + 流体平衡用 Peng-Robinson 状态方程和经典范德华混合规则建模。用 2-9% w/w 乙醇改性的超临界 CO ₂固体多组分混合物的萃取实验，在单程中试规模设备中进行，温度分别为 308 K、323 K 和 338 K，压力分别为 18 MPa、26兆帕和 34 兆帕。对于每个样品，评估松柏素含量。油树脂和松香素的提取曲线用经验模型表示，从中估计油树脂分配常数，范围为 0.03 至 0.13 kg/kg 底物/CO ₂取决于提取条件。然而，分配常数几乎保持不变，与提取温度和压力条件的变化以及 CO _{2 中}的乙醇含量无关，平均值为 0.08 kg/kg 底物/CO ₂。这些结果将有助于使用简化的传质模型来描述从蒸汽蒸馏的 L. origanoides 中提取油树脂。