Diffuse large B cell lymphoma (DLBCL) is a markedly phenotypically heterogenous disease, frequently assessed using bulk genomic techniques that blur the intrinsic heterogeneity of each tumor. In this issue of Cancer Cell, Steen et al. have utilized a computational framework called EcoTyper to skillfully dissect bulk transcriptomic tumor profiles into different cell type components in an unsupervised manner.

中文翻译：

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剖析弥漫性大 B 细胞淋巴瘤的大量转录组

弥漫性大 B 细胞淋巴瘤 (DLBCL) 是一种明显的表型异质性疾病，经常使用大量基因组技术进行评估，这些技术模糊了每个肿瘤的内在异质性。在本期《癌细胞》中，Steen 等人。已经利用称为 EcoTyper 的计算框架，以无监督的方式巧妙地将大量转录组肿瘤谱分解为不同的细胞类型成分。