According to the World Health Organization, diabetes was the seventh leading cause of death in 2016. Long-term diabetes complications are associated with hyperglycemia. It is difficult to predict the beginning and evolution of those complications. The goal of the study was to evaluate the relationship between glycemia and blood spectroscopic variables in an experimental model of type 1 diabetes (streptozotocin model). Blood samples were taken weekly (10 weeks) from the tail of male Wistar rats with or without diabetes. Blood optical absorption spectra were obtained by means of photoacoustic spectroscopy. It was possible to estimate the time-course of blood characteristic peak ratios. The area under the curve of those peaks correlated with hyperglycemia. The evolution of the optical absorption at 450 nm, related to cytochrome p450, was obtained by using the phase-resolved method. The area under the curve of p450 correlated also with hyperglycemia. It is concluded that photoacoustic spectroscopy is a reliable technology to detect the effects of hyperglycemia on blood with possible applications in the study of long-term diabetes complications.

根据世界卫生组织的数据，糖尿病是 2016 年的第七大死因。长期糖尿病并发症与高血糖有关。很难预测这些并发症的开始和演变。该研究的目的是在 1 型糖尿病实验模型（链脲佐菌素模型）中评估血糖与血液光谱变量之间的关系。每周（10 周）从患有或不患有糖尿病的雄性 Wistar 大鼠的尾部采集血样。通过光声光谱法获得血液光学吸收光谱。可以估计血液特征峰比率的时间过程。这些峰的曲线下面积与高血糖症相关。450 nm 处光吸收的演变，与细胞色素 p450 相关，用相分辨法得到。p450 曲线下面积也与高血糖相关。结论是光声光谱是检测高血糖对血液影响的可靠技术，可能应用于长期糖尿病并发症的研究。