Beta-glucan has been shown to have a beneficial effect on gastrointestinal health. This experiment was conducted to investigate the effects of β-glucan isolated from Agrobacterium sp. ZX09 on growth performance and intestinal health of weaning pigs. A total of 108 weaned pigs (21 d of age; 6.05 ± 0.36 kg) were randomly divided into 3 groups (6 pens/group; 6 pigs/pen), and the groups were each treated with the following diets: 1) basal diet, 2) basal diet supplemented with 20 mg/kg olaquindox, 3) basal diet supplemented with 200 mg/kg β-glucan, for 21 d. Compared with the control group, pigs fed with 200 mg/kg β-glucan had greaterBW, average daily gain and duodenal villus height to crypt depth ratio (P < 0.05). Olaquindox increased the duodenal or jejunal villus height of pigs compared with β-glucan. Compared with the control group, β-glucan tended to increase the occludin mRNA expression in the jejunum (0.05 < P < 0.10). Beta-glucan enriched the beneficial microbiota in the ileum of pigs (P < 0.05). In conclusion, β-glucan may promote growth performance by improving intestinal health and increasing beneficial microbiota of weaned pigs. The study results will provide valuable theoretical guidance for the utilization of β-glucan in weaned pigs.

β-葡聚糖已被证明对胃肠道健康有益。进行该实验以研究从农杆菌属中分离的 β-葡聚糖的影响。ZX09对断奶仔猪生长性能和肠道健康的影响。108头断奶仔猪（21日龄；6.05±0.36kg）随机分为3组（6圈/组；6头/圈），各组饲喂以下日粮：1）基础日粮, 2) 基础日粮添加 20 mg/kg 喹乙醇，3) 基础日粮添加 200 mg/kg β-葡聚糖，持续 21 天。与对照组相比，饲喂 200 mg/kg β-葡聚糖的猪具有更高的体重、平均日增重和十二指肠绒毛高度与隐窝深度之比（P < 0.05)。与β-葡聚糖相比，喹乙醇增加了猪的十二指肠或空肠绒毛高度。与对照组相比，β-葡聚糖倾向于增加空肠中occludin mRNA的表达（0.05 <  P  < 0.10）。β-葡聚糖丰富了猪回肠中的有益微生物群（P  < 0.05）。总之，β-葡聚糖可以通过改善肠道健康和增加断奶猪的有益微生物群来促进生长性能。研究结果将为断奶仔猪β-葡聚糖的利用提供有价值的理论指导。