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Association of plasma FGF21 levels with muscle mass and muscle strength in a national multicentre cohort study: Korean Frailty and Aging Cohort Study
Age and Ageing ( IF 6.7 ) Pub Date : 2021-09-10 , DOI: 10.1093/ageing/afab178
Eun Roh 1 , Soon Young Hwang 2 , Hye Jin Yoo 1 , Sei Hyun Baik 1 , Belong Cho 3 , Yong Soon Park 4 , Hyeon Ju Kim 5 , Sam-Gyu Lee 6 , Bong Jo Kim 7 , Hak Chul Jang 8 , Miji Kim 9 , Chang Won Won 10 , Kyung Mook Choi 1
Affiliation  

Background despite of the beneficial effects of fibroblast growth factor (FGF) 21 in several metabolic diseases, the association of plasma FGF21 with muscle mass and muscle strength is still unclear. Methods a total of 386 community-dwelling older adults aged 70–84 years were analysed. Appendicular skeletal muscle mass was measured using dual-energy X-ray absorptiometry and normalised to the square of height (ASM/ht2). Muscle strength was assessed using the hand grip strength (HGS) test. The definitions of low muscle mass (LMM) and low muscle strength (LMS) were based on the Asian Working Group for Sarcopenia. Results plasma FGF21 was significantly lower in participants with LMM than in those with normal muscle mass (289.7 [192.4–448.3] vs. 345.6 [238.6–503.2] pg/ml, P = 0.008). In contrast, the LMS group had a significantly higher plasma FGF21 level than the normal muscle strength group (369.7 [244.4–591.1] vs. 309.7 [205.3–444.8] pg/ml, P = 0.006). In the partial correlation analysis, following adjustment for age, sex and body mass index, FGF21 levels had no significant association with ASM/ht2, but were negatively associated with HGS (r = −0.112, P = 0.029). Furthermore, after multivariate adjustment for confounding variables, the odds ratio for the risk of LMS was 2.32 (95% confidence interval 1.20–4.46) when comparing the highest with the lowest FGF21 quartile. Conclusions circulating FGF21 levels are negatively associated with muscle strength but are not independently correlated with muscle mass.

中文翻译:

一项国家多中心队列研究中血浆 FGF21 水平与肌肉质量和肌肉力量的关联:韩国衰弱和衰老队列研究

背景 尽管成纤维细胞生长因子 (FGF) 21 在几种代谢疾病中具有有益作用,但血浆 FGF21 与肌肉质量和肌肉力量的关联仍不清楚。方法共分析了 386 名 70-84 岁的社区老年人。使用双能 X 射线吸收法测量附肢骨骼肌质量,并归一化为高度的平方 (ASM/ht2)。使用手握力(HGS)测试评估肌肉力量。低肌肉量 (LMM) 和低肌肉力量 (LMS) 的定义基于亚洲少肌症工作组。结果 LMM 参与者的血浆 FGF21 显着低于肌肉质量正常的参与者(289.7 [192.4–448.3] vs. 345.6 [238.6–503.2] pg/ml,P = 0.008)。相比之下,LMS 组的血浆 FGF21 水平显着高于正常肌力组(369.7 [244.4–591.1] vs. 309.7 [205.3–444.8] pg/ml,P = 0.006)。在偏相关分析中,调整年龄、性别和体重指数后,FGF21 水平与 ASM/ht2 无显着相关性,但与 HGS 呈负相关(r = -0.112,P = 0.029)。此外,在对混杂变量进行多变量调整后,比较最高和最低 FGF21 四分位数时,LMS 风险的优势比为 2.32(95% 置信区间 1.20-4.46)。结论 循环 FGF21 水平与肌肉力量呈负相关,但与肌肉质量无关。在偏相关分析中,调整年龄、性别和体重指数后,FGF21 水平与 ASM/ht2 无显着相关性,但与 HGS 呈负相关(r = -0.112,P = 0.029)。此外,在对混杂变量进行多变量调整后,比较最高和最低 FGF21 四分位数时,LMS 风险的优势比为 2.32(95% 置信区间 1.20-4.46)。结论 循环 FGF21 水平与肌肉力量呈负相关,但与肌肉质量无关。在偏相关分析中,调整年龄、性别和体重指数后,FGF21 水平与 ASM/ht2 无显着相关性,但与 HGS 呈负相关(r = -0.112,P = 0.029)。此外,在对混杂变量进行多变量调整后,比较最高和最低 FGF21 四分位数时,LMS 风险的优势比为 2.32(95% 置信区间 1.20-4.46)。结论 循环 FGF21 水平与肌肉力量呈负相关,但与肌肉质量无关。32(95% 置信区间 1.20–4.46)比较最高和最低 FGF21 四分位数。结论 循环 FGF21 水平与肌肉力量呈负相关,但与肌肉质量无关。32(95% 置信区间 1.20–4.46)比较最高和最低 FGF21 四分位数。结论 循环 FGF21 水平与肌肉力量呈负相关,但与肌肉质量无关。
更新日期:2021-09-10
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