In total knee arthroplasty (TKA), blood loss continues internally after surgery is complete. Typically, the total loss over 48 postoperative hours can be around 1,300 ml, with most occurring within the first 24 hours. We hypothesize that the full potential of tranexamic acid (TXA) to decrease TKA blood loss has not yet been harnessed because it is rarely used beyond the intraoperative period, and is usually withheld from 'high-risk' patients with a history of thromboembolic, cardiovascular, or cerebrovascular disease, a patient group who would benefit greatly from a reduced blood loss.

中文翻译：

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术后额外 24 小时口服氨甲环酸与术前单次静脉注射相比，减少全膝关节置换术中的失血量：随机对照试验的结果 (TRAC-24)。

在全膝关节置换术 (TKA) 中，手术完成后内部会继续失血。通常，术后 48 小时内的总流失量约为 1,300 毫升，大部分发生在前 24 小时内。我们假设氨甲环酸 (TXA) 减少 TKA 失血的全部潜力尚未得到利用，因为它很少在术中后使用，并且通常不用于有血栓栓塞、心血管病史的“高危”患者。 ，或脑血管疾病，一个将从减少的失血中大大受益的患者群体。