Zebrafish is an important animal model, which is used to study development, pathology, and genetic research. The zebrafish skin model is widely used in cutaneous research, and angiogenesis is critical for cutaneous wound healing. However, limited by the penetration depth, the available optical methods are difficult to describe the internal skin structure and the connection of blood vessels between the skin and subcutaneous tissue. By a homemade high-resolution polarization-sensitive optical coherence tomography (PS-OCT) system, we imaged the polarization contrast of zebrafish skin and the zebrafish skin vasculature with optical coherence tomography angiography (OCTA). Based on these OCT images, the spatial distribution of the zebrafish skin vasculature was described. Furthermore, we monitored the healing process of zebrafish cutaneous wounds. We think the high-resolution PS-OCT system will be a promising tool in studying cutaneous models of zebrafish.

中文翻译：

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用于斑马鱼皮肤成像的高分辨率偏振敏感光学相干断层扫描和光学相干断层扫描血管造影

斑马鱼是一种重要的动物模型，用于研究发育、病理学和遗传研究。斑马鱼皮肤模型广泛用于皮肤研究，血管生成对于皮肤伤口愈合至关重要。然而，受限于穿透深度，现有的光学方法难以描述皮肤内部结构以及皮肤与皮下组织之间的血管连接。通过自制的高分辨率偏振敏感光学相干断层扫描 (PS-OCT) 系统，我们利用光学相干断层扫描血管造影 (OCTA) 对斑马鱼皮肤和斑马鱼皮肤血管系统的偏振对比度进行了成像。基于这些 OCT 图像，描述了斑马鱼皮肤脉管系统的空间分布。此外，我们监测了斑马鱼皮肤伤口的愈合过程。