ABSTRACT

Purpose

This study aimed to evaluate macular perfusion using optical coherence tomography angiography (OCTA) in patients with cone dystrophy and to determine the associations between the quantitative data of OCTA and functional parameters.

Methods

The data of 36 eyes of 18 patients with cone dystrophy and 38 eyes of 19 healthy controls were analyzed. The superficial and deep capillary plexus (SCP and DCP) vessel densities (VD) of the macula, the foveal avascular zone (FAZ) and choriocapillary flow density values were obtained using OCTA. The associations between visual acuity (VA) and full-field electroretinography (ffERG) and the quantitative data of OCTA, and the associations between OCTA and ffERG were analyzed.

Results

: VD was significantly lower in all areas except the foveal area in SCP in the cone dystrophy group compared to the control group. VA was found to be associated with the VDs of the SCP and DCP except for that of the foveal SCP. VA was also associated with dark-adapted, light-adapted wave amplitudes.

Conclusion

OCTA quantitatively showed that macular perfusion was decreased in cone dystrophy compared to the healthy controls. In addition, there was an association between VA and ffERG parameters and quantitative data of OCTA.

中文翻译：

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锥体营养不良患者的光学相干断层扫描血管造影

摘要

目的

本研究旨在使用光学相干断层扫描血管造影 (OCTA) 评估锥体营养不良患者的黄斑灌注，并确定 OCTA 的定量数据与功能参数之间的关联。

方法

分析了18名锥体营养不良患者的36只眼和19名健康对照者的38只眼的资料。使用 OCTA 获得了黄斑的浅表和深部毛细血管丛 (SCP 和 DCP) 血管密度 (VD)、中心凹无血管区 (FAZ) 和脉络膜毛细血管血流密度值。分析视力（VA）和全视野视网膜电图（ffERG）与OCTA定量数据的关联，以及OCTA与ffERG之间的关联。

结果

：与对照组相比，锥体营养不良组中除 SCP 中央凹区域外的所有区域的 VD 均显着降低。发现 VA 与 SCP 和 DCP 的 VD 相关，除了中央凹 SCP 的 VD。VA 还与适应暗、适应光的波幅有关。

结论

OCTA 定量显示，与健康对照组相比，锥体营养不良患者的黄斑灌注减少。此外，VA 和 ffERG 参数与 OCTA 的定量数据之间存在关联。