In this study, sustained and pH-responsive delivery of drugs were conducted using sealed microcontainers (MCs). The MCs were fabricated using a polydimethylsiloxane (PDMS) stencil. The polymer solution was filled into holes of the stencil space; then, the organic solvent was evaporated to obtain MCs. Poly(lactic-co-glycolic acid) (PLGA) was used as the material for the MCs. The MCs were sealed by covering them with a lid layer after filling the model drug—metronidazole—into the MCs. The diameter and height of the fabricated MCs were 500 and 350 µm, respectively. The drug delivery of sealed MCs was analyzed using the absorbance of the released drug while varying the pH and observing the FE-SEM image, before and after drug release. MCs are expected to be useful in various biomedical applications of drug delivery and microfluidic systems by supporting various functional materials in pH-responsive MCs.

在这项研究中，使用密封微容器 (MC) 进行药物的持续和 pH 响应递送。MC 是使用聚二甲基硅氧烷 (PDMS) 模板制造的。将聚合物溶液填充到模板空间的孔中；然后，蒸发有机溶剂以获得MC。聚（乳酸 - 共 - 乙醇酸）（PLGA）用作 MC 的材料。在将模型药物甲硝唑填充到 MC 中后，通过用盖子层覆盖它们来密封 MC。制造的 MCs 的直径和高度分别为 500 和 350 µm。使用释放药物的吸光度分析密封 MCs 的药物递送，同时改变 pH 值并观察药物释放前后的 FE-SEM 图像。