Bimanual cooperation plays a vital role in functions of the upper extremity and daily activities. Based on the principle of bilateral movement, mirror therapy could provide bimanual cooperation training. However, conventional mirror therapy could not achieve the isolation of the mirror. A novel paradigm mirror therapy called associated mirror therapy (AMT) was proposed to achieve bimanual cooperation task-based mirror visual feedback isolating from the mirror. The study was aimed at exploring the feasibility and effectiveness of AMT on stroke patients. We conducted a single-blind, randomized controlled trial. Thirty-six eligible patients were equally assigned into the experimental group (EG) receiving AMT and the control group (CG) receiving bimanual training without mirroring for five days/week, lasting four weeks. The Fugl-Meyer Assessment Upper Limb subscale (FMA-UL) for upper extremity motor impairment was used as the primary outcome. The secondary outcomes were the Box and Block Test (BBT) and Functional Independence Measure (FIM) for motor and daily function. All patients participated in trials throughout without adverse events or side effects. The scores of FMA-UL and FIM improved significantly in both groups following the intervention. Compared to CG, the scores of FMA-UL and FIM were improved more significantly in EG after the intervention. The BBT scores were improved significantly for EG following the intervention, but no differences were found in the BBT scores of CG after the intervention. However, no differences in BBT scores were observed between the two groups. In summary, our study suggested that AMT was a feasible and practical approach to enhance the motor recovery of paretic arms and daily function in stroke patients. Furthermore, AMT may improve manual dexterity for poststroke rehabilitation.

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相关镜像疗法可增强中风后上肢的运动恢复和日常功能：随机对照研究

双手合作对于上肢功能和日常活动起着至关重要的作用。镜像疗法基于双边运动的原理，可以进行双手合作训练。然而，传统的镜子疗法无法实现镜子的隔离。提出了一种称为关联镜像疗法（AMT）的新颖范式镜像疗法，以实现与镜子隔离的基于双手合作任务的镜像视觉反馈。该研究旨在探讨AMT对中风患者的可行性和有效性。我们进行了一项单盲、随机对照试验。36 名符合条件的患者被平均分配到接受 AMT 的实验组（EG）和接受每周 5 天不镜像双手训练的对照组（CG），持续 4 周。上肢运动障碍的 Fugl-Meyer 上肢评估量表 (FMA-UL) 被用作主要结果。次要结果是运动和日常功能的盒子和块测试（BBT）和功能独立测量（FIM）。所有患者全程参与试验，没有出现不良事件或副作用。干预后，两组的 FMA-UL 和 FIM 评分均显着改善。与CG相比，干预后EG的FMA-UL和FIM评分改善更为显着。干预后EG的BBT评分显着提高，但干预后CG的BBT评分没有差异。然而，两组之间的 BBT 分数没有观察到差异。总之，我们的研究表明，AMT 是增强中风患者瘫痪手臂运动恢复和日常功能的可行且实用的方法。此外，AMT 可以提高中风后康复的手部灵活性。