Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA) metabolism might be involved. The aim of the present study was to clarify the contribution of liver and gut microbiota to BA metabolism disturbance in cancer cachexia and to check the possibility of targeting BA metabolism using agents such as tauroursodeoxycholic acid (TUDCA) for cancer cachexia therapy.

中文翻译：

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胆汁酸代谢失调与癌症恶病质有关：肝脏和肠道微生物组的作用

癌症恶病质是一种多因素代谢综合征，其中可能涉及胆汁酸 (BA) 代谢。本研究的目的是阐明肝脏和肠道微生物群对癌症恶病质中 BA 代谢紊乱的影响，并检查使用牛磺熊去氧胆酸 (TUDCA) 等药物靶向 BA 代谢治疗癌症恶病质的可能性。