Gait disturbance and musculoskeletal changes are evident in persons living with Alzheimer's disease (AD). Because complex gait control requires the integration of neural networks, cerebral small vessel disease (SVD), which is highly prevalent in persons with AD, might have an additional impact on gait disturbance. This study investigated whether white matter hyperintensities (WMH) are more predominantly associated with gait disturbance in persons with AD than in individuals with mild cognitive impairment (MCI) and normal cognition (NC) and further identified the regional impact of WMH on specific gait changes.

中文翻译：

---

区域白质高信号对阿尔茨海默病和轻度认知障碍患者特定步态功能的影响

步态障碍和肌肉骨骼变化在阿尔茨海默病 (AD) 患者中很明显。由于复杂的步态控制需要整合神经网络，因此在 AD 患者中高度流行的脑小血管疾病 (SVD) 可能对步态障碍产生额外的影响。本研究调查了与轻度认知障碍 (MCI) 和正常认知 (NC) 患者相比，白质高信号 (WMH) 是否更主要与 AD 患者的步态障碍相关，并进一步确定了 WMH 对特定步态变化的区域影响。