Effect of high-dose posaconazole on serum levels in adult patients with hematologic malignancy,Antimicrobial Agents and Chemotherapy

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Effect of high-dose posaconazole on serum levels in adult patients with hematologic malignancy
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-09-27 , DOI: 10.1128/aac.01230-21
Adam J DiPippo ₁ , Patrick M McDaneld ₁ , Frank P Tverdek ₁ , Dimitrios P Kontoyiannis ₂

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Posaconazole (POS) appears to have dose-proportional pharmacokinetics, however there is paucity of real-life data. We retrospectively evaluated 67 patients with hematological cancer who had POS dose increase from 300 mg/d to either 400 mg/d (n=52) or 300 ...

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