Tagged cyclophellitols offer a powerful activity-based probe (ABP) approach to the study of glycosidase activities. Here, a range of cyclophellitol epoxide and aziridine inhibitors and ABPs were synthesised and investigated on the 3D structure of human β-glucocerebrosidase (GBA), demonstrating their mechanism-based mode of action. We envisage these inactivators will serve useful in the study of GBA in relation to Gaucher Disease.

中文翻译：

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葡萄糖脑苷脂酶显像剂的设计、合成和结构分析

标记的环酚为研究糖苷酶活性提供了一种强大的基于活性的探针 (ABP) 方法。在这里，合成了一系列环酚醇环氧化物和氮丙啶抑制剂和 ABP，并研究了人类 β-葡萄糖脑苷脂酶 (GBA) 的 3D 结构，证明了它们基于机制的作用模式。我们设想这些灭活剂将有助于研究与戈谢病相关的 GBA。