This study compares the effects on motor symptoms between conventional deep brain stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with Parkinson’s Disease. The aDBS stimulation is controlled by the power in the beta band (12–35 Hz) of local field potentials recorded directly by subthalamic nucleus electrodes. Eight subjects were assessed in two 8-h stimulation sessions (first day, cDBS; second day, aDBS) with regular levodopa intake and during normal daily activities. The Unified Parkinson’s Disease Rating Scale (UPDRS) part III scores, the Rush scale for dyskinesias, and the total electrical energy delivered to the tissues per second (TEEDs) were significantly lower in the aDBS session (relative UPDRS mean, cDBS: 0.46 ± 0.05, aDBS: 0.33 ± 0.04, p = 0.015; UPDRS part III rigidity subset mean, cDBS: 2.9143 ± 0.6551 and aDBS: 2.1429 ± 0.5010, p = 0.034; UPDRS part III standard deviation cDBS: 2.95, aDBS: 2.68; p = 0.047; Rush scale, cDBS 2.79 ± 0.39 versus aDBS 1.57 ± 0.23, p = 0.037; cDBS TEEDs mean: 28.75 ± 3.36 µj s⁻¹, aDBS TEEDs mean: 16.47 ± 3.33, p = 0.032 Wilcoxon’s sign rank test). This work further supports the safety and effectiveness of aDBS stimulation compared to cDBS in a daily session, both in terms of motor performance and TEED to the patient.

本研究比较了传统深部脑刺激 (cDBS) 和闭环自适应深部脑刺激 (aDBS) 对帕金森病患者运动症状的影响。aDBS 刺激由丘脑底核电极直接记录的局部场电位的 β 波段 (12-35 Hz) 中的功率控制。八名受试者在两个 8 小时的刺激期（第一天，cDBS；第二天，aDBS）中接受了定期左旋多巴摄入和正常日常活动的评估。统一帕金森病评定量表 (UPDRS) 第 III 部分评分、运动障碍 Rush 量表和每秒传递到组织的总电能 (TEED) 在 aDBS 会话中显着降低（相对 UPDRS 平均值，cDBS：0.46 ± 0.05 , aDBS: 0.33 ± 0.04, p = 0.015; UPDRS 第三部分刚性子集平均值，cDBS：2.9143 ± 0.6551 和 aDBS：2.1429 ± 0.5010，p  = 0.034；UPDRS 第三部分标准差 cDBS：2.95，aDBS：2.68；p  = 0.047；Rush 量表，cDBS 2.79 ± 0.39 与 aDBS 1.57 ± 0.23，p  = 0.037；cDBS TEED 平均值：28.75 ± 3.36 µj s ^-1，aDBS TEED 平均值：16.47 ± 3.33，p  = 0.032 Wilcoxon 符号秩检验）。与 cDBS 相比，这项工作进一步支持了 aDBS 刺激的安全性和有效性，无论是在运动表现还是对患者的 TEED 方面。