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Human Melioidosis Caused by Novel Transmission of Burkholderia pseudomallei from Freshwater Home Aquarium, United States
Emerging Infectious Diseases ( IF 11.8 ) Pub Date : 2021-09-27 , DOI: 10.3201/eid2712.211756
Patrick Dawson , Monique M. Duwell , Mindy G. Elrod , Ruth J. Thompson , David A. Crum , Ruth M. Jacobs , Jay E. Gee , Cari B. Kolton , Lindy Liu , David D. Blaney , LaToya Griffin Thomas , Denise Sockwell , Zachary Weiner , William A. Bower , Alex R. Hoffmaster , Johanna S. Salzer

Nearly all cases of melioidosis in the continental United States are related to international travel to areas to which Burkholderia pseudomallei, the bacterium that causes melioidosis, is endemic. We report the diagnosis and clinical course of melioidosis in a patient from the United States who had no international travel history and the public health investigation to determine the source of exposure. We tested environmental samples collected from the patient’s home for B. pseudomallei by PCR and culture. Whole-genome sequencing was conducted on PCR-positive environmental samples, and results were compared with sequences from the patient’s clinical specimen. Three PCR-positive environmental samples, all collected from a freshwater home aquarium that had contained imported tropical fish, were a genetic match to the clinical isolate from the patient. This finding suggests a novel route of exposure and a potential for importation of B. pseudomallei, a select agent, into the United States from disease-endemic areas.



中文翻译:

美国淡水家庭水族馆新传播的假马氏伯克霍尔德氏菌引起的人类类鼻疽

美国大陆几乎所有的类鼻疽病例都与国际旅行到导致类鼻疽的细菌伯克霍尔德氏菌流行的地区有关。我们报告了一位没有国际旅行史的美国患者的类鼻疽的诊断和临床过程,以及确定接触源的公共卫生调查。我们测试了从患者家中收集的环境样本中的B. pseudomallei通过 PCR 和培养。对 PCR 阳性的环境样本进行全基因组测序,并将结果与​​患者临床标本的序列进行比较。三份 PCR 阳性的环境样本均来自一个装有进口热带鱼的家庭淡水水族箱,与患者的临床分离物基因匹配。这一发现表明了一种新的接触途径,并且有可能从疾病流行地区将选择性病原体B. pseudomallei输入美国。

更新日期:2021-09-28
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