Lipoprotein lipase (LPL) is responsible for the lipolytic processing of triglyceride-rich lipoproteins, the deficiency of which causes severe hypertriglyceridemia. Liver LPL expression is high in suckling rodents but relatively low at adulthood. However, the regulatory mechanism and functional significance of liver LPL expression are incompletely understood. We have established the zinc finger protein ZBTB20 as a critical factor for hepatic lipogenesis. Here, we evaluated the role of ZBTB20 in regulating liver Lpl gene transcription and plasma triglyceride metabolism.

中文翻译：

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含有 ZBTB20 蛋白的锌指和 BTB 结构域通过抑制肝细胞脂蛋白脂肪酶基因转录来调节血浆甘油三酯代谢

脂蛋白脂肪酶 (LPL) 负责富含甘油三酯的脂蛋白的脂解加工，其缺乏会导致严重的高甘油三酯血症。肝脏 LPL 表达在哺乳期啮齿动物中很高，但在成年期相对较低。然而，肝脏 LPL 表达的调控机制和功能意义尚不完全清楚。我们已将锌指蛋白 ZBTB20 确定为肝脂肪生成的关键因素。在这里，我们评估了 ZBTB20 在调节肝脏Lpl基因转录和血浆甘油三酯代谢中的作用。