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Endoplasmic reticulum stress promotes HBV production by enhancing use of the autophagosome/multivesicular body axis
Hepatology ( IF 13.5 ) Pub Date : 2021-09-28 , DOI: 10.1002/hep.32178
Xueyu Wang 1, 2 , Zhiqiang Wei 2, 3 , Bin Cheng 3 , Jia Li 2 , Yulin He 3 , Tingyu Lan 3 , Thekla Kemper 2 , Yong Lin 4 , Bin Jiang 3, 5 , Yongfang Jiang 1 , Zhongji Meng 3, 6 , Mengji Lu 2
Affiliation  

HBV infection has been reported to trigger endoplasmic reticulum (ER) stress and initiate autophagy. However, how ER stress and autophagy influence HBV production remains elusive. Here, we studied the effect of tunicamycin (TM), an N-glycosylation inhibitor and ER stress inducer, on HBV replication and secretion and examined the underlying mechanisms.

中文翻译:

内质网应激通过增强自噬体/多泡体轴的使用促进 HBV 的产生

据报道,HBV 感染会引发内质网 (ER) 应激并启动自噬。然而,ER 应激和自噬如何影响 HBV 的产生仍然不清楚。在这里,我们研究了衣霉素 (TM)(一种N-糖基化抑制剂和 ER 应激诱导剂)对 HBV 复制和分泌的影响,并研究了其潜在机制。
更新日期:2021-09-28
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