Chronic immune diseases are often reported to be on the rise and are speculated to share early life risk factors. Here, we investigated year of birth as a common denominator for time trends using the consistent data source of the Danish National Patient Registry with 35 years nationwide coverage. Observational nationwide birth cohort registry study, where persons born in Denmark since 1953 were investigated for chronic immune diseases per person years at risk. Outcomes were defined by inpatient hospitalizations in pre-chosen age bins by year of birth in 5 year bins. A population of 3.8 million persons born in Denmark since 1953 was investigated for a total sum of 68 million person years in the ages 5–34 years. We found increasing trends by year of birth for juvenile arthritis age 10–14, adult asthma age 20–24, inflammatory bowel diseases age 20–24, and multiple sclerosis age 25–29, whereas type 1 diabetes age 15–19 was declining until birth year mid 1980s followed by a subsequent increase. Childhood asthma age 5–9 inpatient hospitalizations were relatively stable over time. Nationwide introduction of measles, mumps, rubella vaccine in 1987 did not alter the trends. Hospitalization for the chronic immune diseases adult asthma, juvenile arthritis, inflammatory bowel diseases and multiple sclerosis showed a general increasing trend by birth year in recent 35 years while diabetes 1 and childhood asthma seemed stable in this period. These results were not affected by the introduction of vaccinations against the major childhood viral infections.

据报道，慢性免疫疾病经常呈上升趋势，并被推测与早期生活风险因素有关。在这里，我们使用丹麦国家患者登记处覆盖全国 35 年的一致数据源调查出生年份作为时间趋势的公分母。观察性全国出生队列登记研究，对自 1953 年以来在丹麦出生的人进行了每人每年有风险的慢性免疫疾病的调查。结果由预先选择的年龄组中的住院住院患者按 5 岁组中的出生年份定义。对 1953 年以来在丹麦出生的 380 万人口进行了调查，对 5-34 岁年龄段的总人口数为 6800 万人年。我们发现 10-14 岁幼年关节炎、20-24 岁成人哮喘、20-24 岁炎症性肠病、25-29 岁的多发性硬化症，而 15-19 岁的 1 型糖尿病在 1980 年代中期之前一直在下降，随后又增加。随着时间的推移，5-9 岁儿童哮喘住院率相对稳定。1987 年在全国范围内引入麻疹、腮腺炎、风疹疫苗并没有改变这一趋势。慢性免疫疾病成人哮喘、幼年关节炎、炎症性肠病和多发性硬化症的住院率在近35年中按出生年份总体呈上升趋势，而糖尿病1和儿童哮喘在此期间似乎稳定。这些结果不受引入针对主要儿童病毒感染的疫苗接种的影响。随着时间的推移，5-9 岁儿童哮喘住院率相对稳定。1987 年在全国范围内引入麻疹、腮腺炎、风疹疫苗并没有改变这一趋势。慢性免疫疾病成人哮喘、幼年关节炎、炎症性肠病和多发性硬化症的住院率在近35年中按出生年份总体呈上升趋势，而糖尿病1和儿童哮喘在此期间似乎稳定。这些结果不受引入针对主要儿童病毒感染的疫苗接种的影响。随着时间的推移，5-9 岁儿童哮喘住院率相对稳定。1987 年在全国范围内引入麻疹、腮腺炎、风疹疫苗并没有改变这一趋势。慢性免疫疾病成人哮喘、幼年关节炎、炎症性肠病和多发性硬化症的住院率在近35年中按出生年份总体呈上升趋势，而糖尿病1和儿童哮喘在此期间似乎稳定。这些结果不受引入针对主要儿童病毒感染的疫苗接种的影响。炎症性肠病和多发性硬化症在近 35 年中呈现出按出生年份普遍增加的趋势，而糖尿病 1 和儿童哮喘在此期间似乎稳定。这些结果不受引入针对主要儿童病毒感染的疫苗接种的影响。炎症性肠病和多发性硬化症在近 35 年中呈现出按出生年份普遍增加的趋势，而糖尿病 1 和儿童哮喘在此期间似乎稳定。这些结果不受引入针对主要儿童病毒感染的疫苗接种的影响。