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Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis
Environmental Toxicology ( IF 4.5 ) Pub Date : 2021-09-27 , DOI: 10.1002/tox.23378
Siyu Li 1, 2 , Bing Han 1 , Pengfei Wu 1 , Qingyue Yang 1 , Xiaoqiao Wang 1 , Jiayi Li 1 , Yuge Liao 1 , Ning Deng 1 , Huijie Jiang 1 , Zhigang Zhang 1, 2
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Mercury as a toxic heavy metal will accumulate in the body and induce various diseases through the food chain. However, it is unknown that the detailed mechanism of reproductive disorder induced by inorganic mercury in male mice to date. This study investigated the toxicological effect of mercuric chloride (HgCl2) exposure on reproductive system in male mice. Male Kunming mice received normal saline daily or HgCl2 (3 mg/kg bodyweight) by intraperitoneal injection for a week. The reproductive function was evaluated, and the HgCl2 exposure induced the decline of sperm quality, pregnancy rate, mean litter size, and survival rate. Notably, we firstly found the HgCl2-induced immunosuppression and fibrosis in mice testis according to the results of RNA sequencing. Collectively, these findings demonstrate that HgCl2 exposure disrupts the reproductive system and induces testicular immunosuppression and fibrosis via inhibition of the CD74 signaling pathway in male mice.

中文翻译:

无机汞暴露对雄性小鼠生殖系统的影响:睾丸免疫抑制和纤维化

汞作为有毒重金属,会在体内蓄积,通过食物链诱发各种疾病。然而,迄今为止,无机汞引起雄性小鼠生殖障碍的详细机制尚不清楚。本研究调查了氯化汞 (HgCl 2 ) 暴露对雄性小鼠生殖系统的毒理学影响。雄性昆明小鼠每天接受生理盐水或 HgCl 2 (3 mg/kg 体重) 腹腔注射一周。对生殖功能进行评价,HgCl 2暴露导致精子质量、妊娠率、平均窝产仔数和存活率下降。值得注意的是,我们首先发现了 HgCl 2根据 RNA 测序结果,-诱导小鼠睾丸的免疫抑制和纤维化。总的来说,这些发现表明,HgCl 2暴露会通过抑制雄性小鼠的 CD74 信号通路破坏生殖系统并诱导睾丸免疫抑制和纤维化。
更新日期:2021-12-04
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