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The Association between Carotid Intima-Media Thickness and Cognitive Impairment: A Systematic Review and Meta-Analysis
Dementia and Geriatric Cognitive Disorders ( IF 2.4 ) Pub Date : 2021-09-27 , DOI: 10.1159/000518295
David Fresnais 1, 2 , Mats B Humble 1 , Susanne Bejerot 1, 3 , Adrian Meehan 1, 4 , Brynjar Fure 1, 2
Affiliation  

Background: Emerging evidence suggests that cognitive impairment (CI) and different etiologies of dementia, including Alzheimer’s disease (AD), are associated with vascular risk factors and atherosclerosis. In clinical practice, carotid intima-media thickness (CIMT) measured by ultrasonography may be a marker of atherosclerosis. Many studies report increased CIMT in patients with dementia and CI although a firm association has not yet been established. Aim: This systematic review and meta-analysis were conducted to study the relationship between CIMT, dementia, and CI. Methods: The literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and included the following databases: Medline, Embase, Cochrane Library, and Epistemonikos. The search spanned from 2000 to 2020 and was limited to English and Scandinavian languages. Results: The main analysis of CIMT in subjects with CI compared to subjects with no cognitive impairment (NCI) included 12 studies; 1,089 subjects with CI and 5,223 with NCI. There was no significant difference in CIMT between the CI and NCI groups. However, subgroup analyses revealed significantly higher CIMT in the mild cognitive impairment (MCI) and dementia groups than the NCI group. In addition, patients with dementia had increased CIMT compared to patients with MCI, and patients with AD demonstrated higher CIMT than those with vascular cognitive impairment (VCI). Conclusion: CIMT may be higher in subjects with CI than in cognitively healthy subjects although no significant difference was observed in our main analysis. CIMT was higher in the dementia group than the MCI group and in the AD group compared to the VCI group.
Dement Geriatr Cogn Disord


中文翻译:

颈动脉内中膜厚度与认知障碍之间的关联:系统评价和荟萃分析

背景:新出现的证据表明,认知障碍 (CI) 和痴呆症的不同病因,包括阿尔茨海默病 (AD),与血管危险因素和动脉粥样硬化有关。在临床实践中,超声测量的颈动脉内中膜厚度 (CIMT) 可能是动脉粥样硬化的标志物。许多研究报告了痴呆和 CI 患者 CIMT 增加,尽管尚未建立牢固的关联。目的:本系统评价和荟萃分析旨在研究 CIMT、痴呆和 CI 之间的关系。方法:文献检索是根据系统评价和元分析的首选报告项目指南进行的,包括以下数据库:Medline、Embase、Cochrane 图书馆和 Epistemonikos。搜索范围从 2000 年到 2020 年,仅限于英语和斯堪的纳维亚语。结果:与没有认知障碍 (NCI) 的受试者相比,CI 受试者的 CIMT 主要分析包括 12 项研究;1,089 名 CI 受试者和 5,223 名 NCI 受试者。CI 组和 NCI 组之间的 CIMT 没有显着差异。然而,亚组分析显示轻度认知障碍 (MCI) 和痴呆组的 CIMT 显着高于 NCI 组。此外,与 MCI 患者相比,痴呆患者的 CIMT 增加,AD 患者的 CIMT 高于血管性认知障碍 (VCI)。结论:尽管在我们的主要分析中没有观察到显着差异,但 CI 受试者的 CIMT 可能高于认知健康受试者。痴呆组的 CIMT 高于 MCI 组,AD 组的 CIMT 高于 VCI 组。
老年痴呆症认知障碍
更新日期:2021-09-27
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