Replication of rotavirus, an important cause of gastroenteritis in children, proceeds in large, easily discernible cytoplasmic structures, called viroplasms or viral factories, but mechanisms underlying their formation and function in infected cells have remained mysterious. In this issue, Geiger et al (2021) used a combination of in silico, in vitro, and cell-based approaches to define how two essential rotavirus nonstructural proteins, NSP2 and NSP5, form liquid–liquid phase-separated condensates as the structural foundation of rotavirus factories.

中文翻译：

---

有些病毒需要相分离才能复制

轮状病毒是儿童肠胃炎的一个重要原因，它的复制是在大型、易于识别的细胞质结构中进行的，称为病毒质或病毒工厂，但它们在受感染细胞中形成和功能的机制仍然是个谜。在本期杂志中，Geiger等人(2021) 结合使用计算机、体外和基于细胞的方法来定义两种必需的轮状病毒非结构蛋白 NSP2 和 NSP5 如何形成液-液相分离的缩合物作为结构基础轮状病毒工厂。