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Interaction between dietary total antioxidant capacity and BDNF Val66Met polymorphism on lipid profiles and atherogenic indices among diabetic patients
Scientific Reports ( IF 4.6 ) Pub Date : 2021-09-27 , DOI: 10.1038/s41598-021-98663-9
Faezeh Abaj 1 , Masoumeh Rafiee 2 , Fariba Koohdani 3
Affiliation  

Brain-derived neurotrophic factor (BDNF) belongs to the “neurotrophin” family of growth factors, and it has recently been associated to cardiovascular disease (CVD). We anticipated that BDNF Val66Met polymorphisms may alter CVD risk markers such as serum lipid profile differences, and interaction with total antioxidant capacity of diet (DTAC) could alter these clinical parameters. This cross-sectional study consisted of 667 diabetic patients (39.7% male and 60.3% female). DTAC was calculated by international databases. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2α (PGF2α). interleukin 18 (IL18), leptin and ghrelin were measured by standard protocol. Atherogenic indices (AIP, AC, CR-I, CR-II) were calculated. Genotyping of the BDNF Val66Met polymorphisms was conducted by the real-time PCR–RFLP method. The gene-diet interactions were evaluated using a generalized linear mode (GLMs). Carriers of the Val/Met genotype who were in the higher median intake of FRAP had lower HDL (P:0.04) and higher TG (P:0.005), AIP (P:0.02) and AC (P:0.02) index compared to Val/Val genotypes with lower median intake. Moreover, diabetic patients with Val/Met genotype who consumed higher ORAC intake had increased odds for anthropometric indices (BMI (P:0.01) and WC (P:0.03)), lipid profiles (TG) (P:0.01), and atherogenic index (AIP) (P:0.02), also decreased odds for HDL (P:0.03) concentration compared to reference group whit lower ORAC intake. Individuals with Val/Met genotype who consumed higher TRAP intake had increased odds for WC (P:0.04), TC (P:0.001), TG (P < 0.001), AIP (P < 0.001) and AC (P < 0.001). Finally, Val/Met patients with a higher median intake of TEAC had higher TG (P:0.02), AIP (P:0.009) and AC (P:0.03) compared to the reference group whit lower TEAC intake. Our study showed that Val/Met genotype had also the highest lipid profile and atherogenic indices even in the highest adherence to DTAC. While it seems that the presence of the Val/Val wild-type and BDNF Met/Met homozygotes in diabetic patients with a high DTAC is a protective factor.



中文翻译:

膳食总抗氧化能力与 BDNF Val66Met 多态性对糖尿病患者脂质谱和致动脉粥样硬化指数的相互作用

脑源性神经营养因子 (BDNF) 属于生长因子的“神经营养因子”家族,最近它与心血管疾病 (CVD) 相关。我们预计 BDNF Val66Met 多态性可能会改变 CVD 风险标志物,例如血清脂质特征差异,并且与饮食的总抗氧化能力 (DTAC) 的相互作用可能会改变这些临床参数。该横断面研究包括 667 名糖尿病患者(39.7% 男性和 60.3% 女性)。DTAC 由国际数据库计算得出。生化指标包括总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、甘油三酯(TG)、超氧化物歧化酶(SOD)、C反应蛋白(CRP)、总抗氧化能力(TAC) 、pentraxin-3 (PTX3)、isoprostaneF2α (PGF2α)。白细胞介素 18 (IL18), 瘦素和生长素释放肽通过标准方案测量。计算动脉粥样硬化指数(AIP、AC、CR-I、CR-II)。BDNF Val66Met 多态性的基因分型通过实时 PCR-RFLP 方法进行。使用广义线性模式(GLM)评估基因-饮食相互作用。与 Val 相比,具有较高中位 FRAP 摄入量的 Val/Met 基因型携带者具有较低的 HDL(P:0.04)和较高的 TG(P:0.005)、AIP(P:0.02)和 AC(P:0.02)指数/Val 基因型的中位数摄入量较低。此外,摄入较多 ORAC 的 Val/Met 基因型糖尿病患者的人体测量指标(BMI(P:0.01)和 WC(P:0.03))、血脂(TG)(P:0.01)和致动脉粥样硬化指数的几率增加(AIP) (P:0.02),与 ORAC 摄入量较低的参考组相比,HDL (P:0.03) 浓度的几率也降低。摄入较多 TRAP 的 Val/Met 基因型个体 WC (P:0.04)、TC (P:0.001)、TG (P < 0.001)、AIP (P < 0.001) 和 AC (P < 0.001) 的几率增加。最后,与具有较低 TEAC 摄入量的参考组相比,具有较高 TEAC 摄入量中位数的 Val/Met 患者具有更高的 TG(P:0.02)、AIP(P:0.009)和 AC(P:0.03)。我们的研究表明,即使在对 DTAC 的依从性最高的情况下,Val/Met 基因型也具有最高的脂质特征和致动脉粥样硬化指数。虽然在具有高 DTAC 的糖尿病患者中存在 Val/Val 野生型和 BDNF Met/Met 纯合子似乎是一个保护因素。与具有较低 TEAC 摄入量的参考组相比,具有较高 TEAC 摄入量中位数的 Val/Met 患者具有较高的 TG(P:0.02)、AIP(P:0.009)和 AC(P:0.03)。我们的研究表明,即使在对 DTAC 的依从性最高的情况下,Val/Met 基因型也具有最高的脂质特征和致动脉粥样硬化指数。虽然在具有高 DTAC 的糖尿病患者中存在 Val/Val 野生型和 BDNF Met/Met 纯合子似乎是一个保护因素。与具有较低 TEAC 摄入量的参考组相比,具有较高 TEAC 摄入量中位数的 Val/Met 患者具有较高的 TG(P:0.02)、AIP(P:0.009)和 AC(P:0.03)。我们的研究表明,即使在对 DTAC 的依从性最高的情况下,Val/Met 基因型也具有最高的脂质特征和致动脉粥样硬化指数。虽然在具有高 DTAC 的糖尿病患者中存在 Val/Val 野生型和 BDNF Met/Met 纯合子似乎是一个保护因素。

更新日期:2021-09-27
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