Although it was known for decades that type I interferons are crucial for antiviral immunity, it was not until the discovery of cGAS and cGAMP signalling in 2013 that we understood how cytosolic DNA induces them in infected cells, as explained by Andrea Ablasser.

中文翻译：

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发现了十亿年前的先天免疫机制

尽管几十年来人们都知道 I 型干扰素对于抗病毒免疫至关重要，但直到 2013 年发现 cGAS 和 cGAMP 信号，我们才了解胞质 DNA 如何在受感染的细胞中诱导它们，正如 Andrea Ablasser 所解释的那样。