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Hexaconazole-Micelle Nanodelivery System Prepared Using Different Surfactants for Ganoderma Antifungal Application
Molecules ( IF 4.6 ) Pub Date : 2021-09-26 , DOI: 10.3390/molecules26195837
Isshadiba Faikah Mustafa 1 , Mohd Zobir Hussein 1 , Abu Seman Idris 2 , Nur Hailini Zainol Hilmi 2 , Sharida Fakurazi 3
Affiliation  

Reports on fungicide-based agronanochemicals in combating disastrous basal stem rot disease in the oil palm industry are scant. Herein, we describe the potential of fungicide nanodelivery agents based on hexaconazole-micelle systems produced using three different surfactants; sodium dodecylbenze sulfonate (SDBS), sodium dodecyl sulfate (SDS) and Tween 80 (T80). The resulting nanodelivery systems were characterized and the results supported the encapsulation of the fungicide into the micelles of the surfactants. We have investigated in detail the size-dependent effects of the as-synthesized micelles towards the inhibition growth of Ganoderma Boninense fungi. All the nanodelivery systems indicate that their size decreased as the surfactant concentration was increased, and it directly affects the fungal inhibition. It was also found that Tween 80, a non-ionic surfactant gave the lowest effective concentration, the EC50 value of 2, on the pathogenic fungus Ganoderma boninense compared to the other anionic surfactants; SDBS and SDS. This study opens up a new generation of agronanofungicide of better efficacy for Ganoderma disease treatment.

中文翻译:

使用不同表面活性剂制备的六康唑-胶束纳米递送系统用于灵芝抗真菌应用

关于在油棕行业中使用基于杀菌剂的农用化学品对抗灾难性的基部茎腐病的报道很少。在此,我们描述了基于使用三种不同表面活性剂生产的六唑 - 胶束系统的杀菌剂纳米递送剂的潜力;十二烷基苯磺酸钠 (SDBS)、十二烷基硫酸钠 (SDS) 和吐温 80 (T80)。对所得纳米递送系统进行表征,结果支持将杀真菌剂封装到表面活性剂的胶束中。我们已经详细研究了合成胶束对Ganoderma Boninense生长抑制的大小依赖性影响菌类。所有纳米递送系统都表明它们的尺寸随着表面活性剂浓度的增加而减小,这直接影响真菌的抑制。还发现,与其他阴离子表面活性剂相比,吐温 80(一种非离子表面活性剂)对病原真菌灵芝的有效浓度最低,EC 50值为 2 ;SDBS 和 SDS。该研究开辟了新一代治疗灵芝疾病疗效更好的农杆菌属真菌剂。
更新日期:2021-09-27
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