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Modulation of hyaluronan signaling as a therapeutic target in human disease
Pharmacology & Therapeutics ( IF 13.5 ) Pub Date : 2021-09-26 , DOI: 10.1016/j.pharmthera.2021.107993
Stavros Garantziotis 1
Affiliation  

The extracellular matrix is an active participant, modulator and mediator of the cell, tissue, organ and organismal response to injury. Recent research has highlighted the role of hyaluronan, an abundant glycosaminoglycan constituent of the extracellular matrix, in many fundamental biological processes underpinning homeostasis and disease development. From this basis, emerging studies have demonstrated the therapeutic potential of strategies which target hyaluronan synthesis, biology and signaling, with significant promise as therapeutics for a variety of inflammatory and immune diseases. This review summarizes the state of the art in this field and discusses challenges and opportunities in what could emerge as a new class of therapeutic agents, that we term “matrix biologics”.



中文翻译:

调节透明质酸信号作为人类疾病的治疗靶点

细胞外基质是细胞、组织、器官和有机体对损伤反应的积极参与者、调节剂和介质。最近的研究强调了乙酰透明质酸的作用,透明质酸是细胞外基质的一种丰富的糖胺聚糖成分,在支持稳态和疾病发展的许多基本生物过程中发挥着重要作用。在此基础上,新兴研究已经证明了靶向透明质酸合成、生物学和信号传导的策略的治疗潜力,作为治疗各种炎症和免疫疾病的重要前景。这篇综述总结了该领域的最新技术,并讨论了可能出现的一类新型治疗药物(我们称之为“基质生物制剂”)的挑战和机遇。

更新日期:2021-09-27
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