Background and Aims. Sarcopenia is a prognostic factor of outcomes for various diseases, but reports on sarcopenia in patients with Crohn’s disease (CD) are few. We aim to determine the prevalence of sarcopenia and assess the role of sarcopenia in postoperative complications in patients with CD at a tertiary referral center. Methods. Patients who underwent intestinal surgery for CD from January 2013 to October 2019 were retrospectively enrolled. The L3 skeletal muscle mass index (SMI) was used to identify sarcopenia. Demographic data, preoperative laboratory data, surgical details, and hospital outcomes were recorded. The factors associated with postoperative complications were evaluated through univariate and multivariate analyses. Results. One hundred and twenty-four patients were enrolled. Thirty-four of them (27.4%), including 11 males, were diagnosed with sarcopenia. Compared with patients without sarcopenia, sarcopenic patients had a significantly lower BMI (); lower preoperative serum albumin (), prealbumin (), and hemoglobin levels (); longer hospital stay ( days vs. days, ); and more occurrences of complications (41.2% vs. 23.3%, ). The overall incidence of postoperative complications was 28.2%. Infection (51.4%) and intestinal fistula (22.9%) were the most common among such complications. Through the multivariate analysis, sarcopenia was identified as an independent risk factor for major postoperative complications (, –13.489, ). Conclusion. Sarcopenia is common in patients with CD requiring bowel resection, and it significantly increases the risk of major postoperative complications.

中文翻译：

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克罗恩病患者肌肉减少症的患病率及其对术后并发症的影响

背景和目标。肌肉减少症是各种疾病结果的预后因素，但关于克罗恩病 (CD) 患者肌肉减少症的报道很少。我们旨在确定肌肉减少症的患病率，并评估肌肉减少症在三级转诊中心 CD 患者术后并发症中的作用。方法。回顾性纳入了 2013 年 1 月至 2019 年 10 月因 CD 接受肠道手术的患者。L3 骨骼肌质量指数 (SMI) 用于识别肌肉减少症。记录人口统计学数据、术前实验室数据、手术细节和医院结果。通过单变量和多变量分析评估与术后并发症相关的因素。结果. 招募了 124 名患者。其中 34 人 (27.4%)，包括 11 名男性，被诊断为肌肉减少症。与没有肌肉减少症的患者相比，肌肉减少症患者的 BMI 显着降低。); 术前血清白蛋白降低（),前白蛋白 ()和血红蛋白水平 (); 住院时间更长（ 天数对比 天， ); 以及更多并发症的发生（41.2% 对 23.3%，）。术后并发症的总发生率为28.2%。感染（51.4%）和肠瘘（22.9%）是此类并发症中最常见的。通过多变量分析，肌肉减少症被确定为术后主要并发症的独立危险因素。, –13.489， ）。 结论。肌肉减少症在需要肠切除的 CD 患者中很常见，并且会显着增加术后主要并发症的风险。