Immune semaphorins are important in controlling both innate and adaptive immune responses. The regulatory role of semaphorin3A (sema3A) in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other autoimmune diseases is widely reported. Decreased levels of serum sema3A were shown to correlate with SLE disease activity. The aim was to assess urine concentrations of sema3A in SLE patients and its correlation with renal involvement and disease activity. Urine levels of sema3A were analyzed in 38 SLE patients, 13 with renal involvement, and were compared to 10 healthy volunteers and 8 RA patients (disease control group). The excretion of urine sema3A was found to be significantly lower in SLE patients compared to healthy volunteers and RA patients (4.9 ± 3.9 ng/ml, 8.5 ± 2.7 ng/ml, 9.85 ± 1.7 ng/ml, respectively, p = 0.0006). Urine sema3A was significantly lower in SLE patients with lupus nephritis than in patients without nephritis (4.0 ± 3.4 ng/ml vs. 6.5 ± 3.8 ng/ml, p = 0.03). Urine sema3A inversely correlated with proteinuria and SLE disease activity. Urine sema3A is decreased in lupus patients and should be further evaluated as a possible biomarker for disease activity and renal involvement.

免疫信号素对于控制先天性和适应性免疫反应都很重要。信号素3A（sema3A）在系统性红斑狼疮（SLE）、类风湿性关节炎（RA）等自身免疫性疾病中的调节作用已被广泛报道。血清 sema3A 水平降低与 SLE 疾病活动性相关。目的是评估 SLE 患者尿液中 sema3A 的浓度及其与肾脏受累和疾病活动的相关性。分析了 38 名 SLE 患者、13 名肾脏受累患者的尿液 sema3A 水平，并与 10 名健康志愿者和 8 名 RA 患者（疾病对照组）进行了比较。与健康志愿者和 RA 患者相比，SLE 患者的尿 sema3A 排泄量显着降低（分别为 4.9 ± 3.9 ng/ml、8.5 ± 2.7 ng/ml、9.85 ± 1.7 ng/ml，p = 0.0006)。患有狼疮性肾炎的 SLE 患者的尿液 sema3A 显着低于没有肾炎的患者（4.0 ± 3.4 ng/ml vs. 6.5 ± 3.8 ng/ml，p = 0.03）。尿液 sema3A 与蛋白尿和 SLE 疾病活动呈负相关。狼疮患者的尿液 sema3A 降低，应作为疾病活动和肾脏受累的可能生物标志物进一步评估。